Effects of a high-protein low-calorie intermittent-fast diet on plasma toxins and oxidative stress following weight loss (LB435)

In obese subjects, the decrease in fat mass with weight loss is generally regarded as beneficial and may favorably alter oxidative stress. However, it also increases the release of polychlorinated biphenyls (PCBs) from fat depots. Thus, the purpose of this study was to examine the effects of a 10 week higher protein-low calorie diet incorporating intermittent fasting (HPLC-IF) on fat mass, plasma toxins (PCBs) and oxidative stress biomarkers, thiobarbituric acid reactive substances (TBARS) and total antioxidant capacity (TAC) in 43 obese men (n=22) and women (n=21). Fat mass, plasma PCBs and oxidative stress biomarkers were assessed at the beginning (pre) and end (post) of the intervention. Following the 10 week HPLC-IF diet, fat mass decreased significantly (P<0.01) in both groups (males, n=21: 47.5 ± 14.8 vs 37.4 ± 13.3; females, n=19: 49.4 ± 9.6 vs 40.8 ± 9, kg) with males losing more fat mass (-21.8 ± 5.5% vs -17.7± 5.3%, P<0.05; respectively). Eight of 11 individual PCB congeners and total PCB concen...