Facile synthesis and isolation of 5-hydroxymethylfurfural from diphenyl sulfoxide
2021
We report diphenyl sulfoxide (DPhSO) as an active, cheap and environmentally friendly solvent to facilely synthesize 5-hydroxymethylfurfural (HMF) from fructose. It acts as both the catalyst and solvent to afford nearly 100% conversion of fructose and 68.4% yield of HMF. In particular, HMF was easily extracted using water and DPhSO froze into an insoluble solid at low temperature. DPhSO was reused 6 times without significant loss of activity. The reaction mechanism of DPhSO-catalyzed HMF formation was analyzed by NMR and ESI-MS experiments and theoretical calculations.
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