Early and late mortality after repair or replacement in mitral valve prolapse and functional ischemic mitral regurgitation: A systematic review and meta-analysis of observational studies

Mitral regurgitation (MR) is the most prevalent valvular pathology in the USA affecting 1.7% of the population [1]. The two predominant forms of MR in the Western World are mitral valve prolapse (MVP) and ischemic mitral regurgitation (IMR) [2]. The optimal surgical strategy is still debated in both entities. Previous data comparing mitral valve repair (MVr) and replacement (MVR) approaches are based on a heterogeneous population in terms of LV function and baseline characteristics. The purpose of this study was to perform a systematic review and meta-analysis of all the relevant studies and to compare the mortality between the 2 surgical treatment strategies in patients with MVP and IMR. Using PubMed database, EMBASE, and the Cochrane Library we performed literature searches and thereafter individually reviewed relevant articles, extracted relevant data and entered in Review Manager software ([RevMan] version 5.1.20 (Nordic Cochrane Centre, Copenhagen, Denmark)).