Internal Radiotherapy Using Radionuclides

Selective internal radiation therapy (SIRT) is a form of locoregional treatment using radiation from radiolabelled particles or ligands for liver cancer. This modality has seen significant advancements in recent times with robust scientific evidence backing the expanding therapeutic applications. The common indications for SIRT are reviewed based on current evidence, including the results of major clinical trials. Technological advances in hybrid imaging and interventional radiology have contributed to the use of planning dosimetry for dose activity prescriptions. There is emerging data to show that this leads to better patient outcomes. The recent phase III trials have also highlighted a good safety profile and better tolerance of SIRT compared to the current standard of care systemic treatment. There is potential for combining external beam radiotherapy with SIRT under certain clinical circumstances and new data will be eagerly expected in this area.