Suzuki-Miyaura Cross-Coupling as a Synthetic Tool for Nucleoside and Nucleotide Modification

Abstract Nucleoside analogues are extremely useful for the development of therapeutic agents to control viral diseases and cancer. The intense search for clinically useful nucleoside derivatives has resulted in a wealth of new approaches to their syntheses. To achieve these goals, palladium-catalyzed chemistry and, especially, Suzuki-Miyaura cross-coupling, have been widely used. The selected article documents, by way of individual case studies, a gathering of recent strategies for the synthesis of active nucleosides.