Hypoxia targeted carbon nanotubes as a sensitive contrast agent for photoacoustic imaging of tumors
2011
Development of new and efficient contrast agents is of fundamental importance to improve detection sensitivity of
smaller lesions. Within the family of nanomaterials, carbon nanotubes (CNT) not only have emerged as a new
alternative and efficient transporter and translocater of therapeutic molecules but also as a photoacoustic molecular
imaging agent owing to its strong optical absorption in the near-infrared region. Drugs, Antibodies and nucleic acids
could functionalize the CNT and prepare an appropriate system for delivering the cargos to cells and organs. In this
work, we present a novel photoacoustic contrast agent which is based on a unique hypoxic marker in the near infrared
region, 2-nitroimidazole -bis carboxylic acid derivative of Indocyanine Green conjugated to single walled carbon
nanotube (SWCNT-2nitroimidazole-ICG). The 2-nitroimidazole-ICG has an absorption peak at 755 nm and an extinction
coefficient of 20,5222 M -1 cm -1 . The conjugation of this marker with SWCNT shows more than 25 times enhancement of
optical absorption of carbon nanotubes in the near infrared region. This new conjugate has been optically evaluated
and shows promising results for high contrast photoacoustic imaging of deeply located tumors. The conjugate
specifically targets tumor hypoxia, an important indicator of tumor metabolism and tumor therapeutic response. The
detection sensitivity of the new contrast agent has been evaluated in-vitro cell lines and with in-vivo tumors in mice.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
3
Citations
NaN
KQI