Colchicine disposition in patients with familial Mediterranean fever with renal impairment

Objective. To assess the pharmacokinetics of serum colchicine in patients with familial Mediterranean fever (FMF) with renal impairment. Methods. Using a specific radioimmunoassay we determined serum colchicine concentration at various time points following oral administration of a single dose of the drug. Results. Patients with renal insufficiency had a mean±SD apparent total colchicine clearance of 0.168±0.063 l/h/kg, apparent volume of distribution of 4.56±1.64 l/kg and elimination half-life (t 1/2 ) of 18.8±1.2 h