RAPID METHOD OF FRIEDEL-CRAFTS ALKYLATION OF PHLOROGLUCINOL BY MICROWAVE IN DRY MEDIA AND REUSABLE CATALYST

ABSTRACT A new rapid and efficient method for the synthesis of a series of alkylated phloroglucinols using conventional microwave is reported 4 phloroglucinol deriva-tives (4, 5, 6 and 7) were synthesized with good yields (~50%) by a Friedel-Crafts reaction through an Electrophilic Aromatic Substitution mechanism between geraniol/prenol and phloroglucinol, using reusable SiO 2 and AgNO 3 as the best catalyst tested without solvents under microwave irradiation. Keywords: Microwave synthesis; alkylated phloroglucinol; AgNO 3 e-mail: marcela.carvajal@usm.cl 1. INTRODUCTION Nowadays, Organic Chemistry is becoming increasingly based on find-ing new technologies and alternative processes to existing ones that will be environmentally friendlier and less toxic (Green Chemistry). Organic synthe -sis processes are not exempt from this trend, because many of these involve solvents or solutions difficult to recycle after reaction and in some cases are highly toxic . Chemical synthesis assisted by microwave is a powerful tool, which when applied to a wide range of chemical reactions allows for important contributions such as: reducing reaction times, high yields, avoiding collateral and substitute products, and the use of toxic solvents.Prenylated and geranylated phenols correspond to an interesting group of marine and plant natural products, with a wide variety of biological ac-tivities described, including anti-inflammatory