LONG-TERM TOXICITY OF "MALTI", A SWEET MATERIAL CONSISTING OF MALTITOL WITH SPECIAL REFERENCE TO TUMORIGENIC ACTIVITY IN RATS.

"Malti" is a commercial sweet material which contains maltitol in a concentration of more than 75 per cent. Groups of male and female Wistar rats were maintained on diets containing "Malti" in concentrations of 3% and 10% for one and a half years (78 weeks), in order to study long-term toxicity with special reference to carcinogenicity. During the experiment, no unusual signs were observed among the test rats. Growth and food consumption data revealed no Malti-related differences. Hematologic parameters and clinical blood chemistry data showed no significant differences except for a lowering of serum cholesterol level in all Malti groups. Pathologic and patho-histologic examinations revealed no diffinite abnormalities. Carcinogenit activity was also negative.