Studies on enema; on the absorption of isonicotinic acid hydrazide in large intestine.

Abstract Previously, the author (1) recognized, in the administration of streptomycin alone as enema or subcutaneous injection in the rabbits, that the blood streptomycin level reaches the maximum at 30 minutes and becomes trace or disappears at 6 hours after the drug alone was administered as enema. However, it was also known that, in the subcutaneous injection of this drug alone, the level reaches the highest value at 1 hour after the administration showing much higher value and much longer period of duration. After the above experiments, as the results of the administration of streptomycin combined with various substances as enema, the following facts were known. When streptomycin was administered as enema in combination with urethane, the blood streptomycin level reaches the maximum at 30 minutes after the administration, and it is proved to be present even after 6 hours, while magnesium sulfate does not show any particular influence on the level. When combined with chloral hydrate, the maximum value is reached at 30 minutes, and the presence of the drug is proved even after more than 6 hours. The blood streptomycin level in this case was also extremely high. Similar results were obtained when streptomycin was administered in combination with the isotonic solution of glucose and taurin together with chloral hydrate. In this case, the highest value was reached at 30 minutes and a high level was maintained even at 1-2 hours after the administration. Even after 6 hours, the level was found to be as high as it could be quantitatively estimated. However, in view of the fact that no clear effect on the absorption of streptomycin was noted in the case of the combination with taurin and glucose, the streptomycin absorption promoting effect of chloral hydrate was considered to be great. Furthermore, cattle bile and spreading factor were tried out in combination with streptomycin, and it was found that no particular effect by Sprase on the absorption of streptomycin in large intestine is exercised. On the other hand, the streptomycin absorption promoting effect of cattle bile was found extremely remarkable, showing a very high blood streptomycin level with a long duration time.