Selection of antigenically advanced variants of seasonal influenza viruses

Chengjun Li,Masato Hatta,David F. Burke,Jihui Ping,Ying Zhang,Makoto Ozawa,Andrew S. Taft,Subash C. Das,Anthony Hanson,Jiasheng Song,Masaki Imai,Peter R. Wilker,Tokiko Watanabe,Shinji Watanabe,Mutsumi Ito,Kiyoko Iwatsuki-Horimoto,Colin A. Russell,Sarah L. James,Eugene Skepner,Eileen A. Maher,Gabriele Neumann,Alexander Klimov,Anne Kelso,John W. McCauley,Dayan Wang,Yuelong Shu,Takato Odagiri,Masato Tashiro,Xiyan Xu,David E. Wentworth,Jacqueline M. Katz,Nancy J. Cox,Derek J. Smith,Yoshihiro Kawaoka

Selection of antigenically advanced variants of seasonal influenza viruses

2016

Antigenic variants from human H1N1 and H3N2 influenza virus libraries possessing random mutations in the haemagglutinin protein, selected by incubation with human and/or ferret convalescent sera, identify escape variants similar to those that have emerged in nature.

Keywords:

Genetics
H5N1 genetic structure
Virus
Antigen
Hemagglutinin
Viral evolution
Antigenic drift
Virology
Biology
seasonal influenza
Mutant

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