Recent Progress in Continuous-Flow Hydrogenation.

To aid safe, more efficient, sustainable, even fully automated mode of production involving continuous-flow hydrogenation reactions, one of the most often used reactions in chemical synthesis, new catalyst types, immobilization methods, flow reactors and technologies have been developed in the last years, along with the new and transformational technologies in other fields such as artificial intelligence. Thus, improved performance of hydrogenation in flow mode such as reduced reaction times, higher selectivities and safe operations have led to increased attention from academic and industry practitioners. This review aims to summarize the most recent (2015-2020) research results on this topic with focuses on the advantages, current limitations and future directions of flow chemistry.