Association between CASP8 –652 6N Del Polymorphism (rs3834129) and Colorectal Cancer Risk: Results from a Multi-Centric Study

This work was supported by COST Action BM1206. Spanish cohort: The authors are sincerely grateful to all patients participating in this study who were recruited in 25 (EPICOLON 1) and 14 (EPICOLON 2) Spanish hospitals as part of the EPICOLON project. The authors are also indebted to the Genomics Unit of the Institut d'Investigacions Biome` diques August Pi i Sunyer for technical help. The work was carried out (in part) at the Esther Koplowitz Centre, Barcelona. SCB is supported by a contract from the Fondo de Investigacion Sanitaria (CP 03-0070 to SCB). Networked Biomedical Research Centre for Hepatic and Digestive Diseases and Centro de Investigacion Biomedica en Red de Enfermedades Raras are funded by the Instituto de Salud Carlos III. This work was supported by grants from the Fondo de Investigacion Sanitaria/FEDER (08/0024, 08/1276, PS09/02368, 11/00219, 11/00681), Instituto de Salud Carlos III (Accion Transversal de Cancer), Xunta de Galicia (07PXIB9101209PR), Ministerio de Ciencia e Innovacion (SAF2010-19273), Asociacion Espanola contra el Cancer (Fundacion Cientifica y Junta de Barcelona), FundacioOlga Torres (SCB and CRP), FP7 CHIBCHA Consortium (SCB and A. Carracedo). Italian cohort: The authors thank all individuals who agreed to participate in the study. The authors also thank the personnel of Tissue Bank of Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto dei Tumori for sample collection and all pathologists for their contribution and collaboration. American cohort: Kentucky Colon Cancer Genetic Epidemiology Study is supported by National Institutes of Health grant R01CA136726 to LL. English cohort: Core funding to the Wellcome Trust Centre for Human Genetics was provided by the Wellcome Trust (090532/Z/09/Z). Czech cohort: Grant agency of the Czech Republic (GACR) [CZ: GACR: GA P304/10/1286 and P304/12/1585] and by Prvouk-P27/LF1/1 from Ministry of Education, Youth and Sport, Czech Republic (First Medical Faculty, Charles University, Prague, Czech Republic as a recipient). Dutch cohort: Dutch Cancer Society, grant KWF-UL-2010-4656.