Impact of Cold Ischemia Time on the Function of Liver Grafts Preserved With Custodiol.

Abstract Objective This study aimed to evaluate how cold ischemia time (CIT) interferes with liver graft function in the first 7 days after surgery for Custodiol (HTK) preserved organs. Methods This retrospective observational study analyzed the medical records of 38 transplantation patients at Hospital Leforte Liberdade, Sao Paulo, in 2018. The study population was divided into 2 groups (group A, CIT  8 hours). Postoperative parameters—such as international normalized ratio, total bilirubin, aspartate aminotransferase/alanine aminotransferase, alkaline phosphatase, gamma glutamyl transferase (GGT), lactate dehydrogenase, lactate, creatinine, red blood cell transfusion, need for hemodialysis, use of vasoactive drugs, endotracheal intubation time, length of stay in the intensive care unit (ICU), and length of hospital stay—were compared. Results Group A (CIT  Conclusion In livers preserved with Custodiol, CIT > 8 hours generated higher levels of total bilirubin and GGT in the postoperative period, in addition to higher hospital costs; greater need for red blood cell transfusions; and longer hospitalization, including longer stays in the ICU.