Diaryl ureas 1,3-substituted as modulators of kinase activity

At least one selected from compounds of Formula 1 ** Formula ** and pharmaceutically acceptable salts, solvates, crystalline forms, and mixtures thereof chemical entity, wherein A is selected from O and S; B and D are selected from CH and N, provided that at least one of B and D is CH; R represents 0-2 substituents independently selected from hydroxy, nitro, cyano, optionally substituted amino, aminocarbonyl, halo, carboxy, optionally substituted acyl, optionally substituted alkoxycarbonyl selected, C1-C6 alkyl optionally substituted, C1-C6 alkoxy optionally substituted sulfanyl, sulfinyl, sulfonyl, optionally substituted aryl, optionally substituted heteroaryl and optionally substituted heterocycloalkyl; R1 is optionally substituted heteroaryl; W is optionally substituted heteroaryl; Z1 is -CR5R6-, wherein each R5 and R6 is independently selected from hydrogen, optionally substituted alkyl and halo C1-C6 alkyl; m is selected from 0, 1 and 2; Z2 is -CR7R8-, wherein each R7 and R8 is independently selected from hydrogen, optionally substituted alkyl and halo C1-C6 alkyl; n is selected from 0, 1 and 2; R2 is optionally substituted aryl; each of R3 and R4 is independently selected from hydrogen, C1-C6 alkyl optionally substituted, optionally substituted aryl and optionally substituted heteroaryl, and wherein "alkyl" refers to straight chain and branched chain having the indicated number of atoms carbon; "Lower alkyl" refers to alkyl groups having one to four carbons; "Alkenyl" refers to an unsaturated alkyl group of straight or branched chain having at least one carbon-carbon double bond derived by the removal of one hydrogen atom from a single carbon atom of a parent alkene.