Morphological manifestations of disorders of renal tissue differentiation in children

Light and electron microscopy were used to study the renal tissues from 160 children varying in ages from 3 months to 15 years suffering from congenital hereditary, and acquired diseases of the urinary system. Signs of disorders in the renal parenchyma differentiation were observed in 98 patients and detected at the tissue and subcellular levels. Morphological elements of renal dysplasia and little-studied structures are described. Signs of differentiation disorders were accompanied by the development of secondary changes making morphological diagnosis of renal abnormalities difficult. The main differences between the disturbed differentiation and pseudofetal structures appearing due to the development of secondary changes are described.