СЕЗОННАЯ ДИНАМИКА МЕЛАТОНИНА, ПРОЛАКТИНА, ПОЛОВЫХ ГОРМОНОВ И ГОРМОНОВ НАДПОЧЕЧНИКОВ У ЗДОРОВЫХ ЛЮДЕЙ: МЕТА-АНАЛИЗ

At present, most researchers believe that circannual fluctuations in the functioning of the human body relate not so much to fluctuations in melatonin levels as to changes in the ambient temperature. The goal of this work was to study the seasonal dynamics of melatonin, prolactin, sex hormones and adrenal hormones in healthy people by a meta-analysis of publications and, based on its outcome, to draw a conclusion on the influence of the photoperiod and atmospheric temperature on seasonal changes in the functioning of the organism of present-day humans. Using Review Manager 5.3, we carried out a meta-analysis of 31 panel and 12 cross-sectional studies devoted to the seasonal dynamics of circulating hormones. We found that the level of circulating norepinephrine and aldosterone increases in winter compared to summer, which, along with the previously established winter increase in the activity of thyroid hormones, corroborates the significant effect of circannual fluctuations in atmospheric temperature on the hormonal status of present-day humans. However, since a number of studies have shown the seasonal dynamics of melatonin, while meta-analysis revealed a significant increase in the average daily prolactin level in women of reproductive age in spring compared to fall, the influence of the photoperiod on our contemporaries cannot be ruled out completely. Hormonal changes, in turn, can cause seasonal changes in physiological parameters and reproductive functions, as well as affect the development and exacerbation of certain pathologies.