Mechanism of eRF3a/GSPT1 in tumor initiation and progression

As a member of the eukaryotic peptide chain release factor family, eRF3a plays an important role in a variety of biological processes. It is encoded by the G1 to S phase transition 1 gene (GSPT1). In recent years, increasing evidence has indicated that eRF3a/GSPT1 is related to initiation and development of the common tumors. This paper is dedicated to depicting the roles of eRF3a/GSPT1 in the tumor development. Key words: Eukaryotic cells; Peptide chain termination; Neoplasms; Molecular mechanisms of pharmacological action