SYNTHESIS AND ANTIMICROBIAL SCREENING OF SOME NOVEL HALOGENATED PHENOXYACETYL AMINO ACID AND PEPTIDE ANALOGS

In present study, a novel series of trisubstituted phenoxyacetyl amino acids and peptide derivatives was synthesized by coupling 2-(2,6-dibromo-4-formylphenoxy)acetic acid with amino acid methyl ester hydrochlorides/peptide methyl esters using DIPC as coupling agent and TEA as base. The structures were elucidated by IR, 1H NMR, 13C NMR and MS spectral data as well as elemental analysis. The newly synthesized peptide derivatives were evaluated for antibacterial and antifungal potential against pathogenic microorganisms. Compounds Ig, Ik and In displayed potent antibacterial activity against gram-negative bacteria Pseudomonas aeruginosa, Escherichia coli and compounds Ic, Ih, Il and Ij, Im were found to exhibit potent antifungal activity against pathogenic Candida albicans and dermatophytes, as compared to standard drugs ciprofloxacin and griseofulvin.