Urine viscosity in the evaluation of homeostasis in heart surgery patients in the early postoperative period

: A total of 100 dynamic measurements of the urinary viscosity were carried out in 38 patients subjected to open-heart surgery. Biochemical parameters and levels of electrolytes were measured in the cystic urine. The viscosity of the urine was found to be unchanged from 10 to 300 sec-1. A significant increase of its level was observed only in acute renal failure and led to the development of multiorgan abnormalities. The results indicate that urine viscosity in the early postoperative period was due to pH values (r = 0.47, p < 0.05) and free hemoglobin level (r = -0.52, p < 0.01) in coronary patients and due to concentrations of sodium (r = -0.57, p < 0.01) and chloride ions (r = 0.38, p < 0.01), osmolarity (r = -0.53, p < 0.1), and protein levels (e = -0.37, p < 0.1) in patients with acquired heart diseases. These causal relations were conditioned by the postoperative directions of regular reactions of homeostasis, because in coronary disease it is virtually the same as before surgery. Contrariwise, renal perfusion has a great impact on homeostasis stabilization in new bloodflow state in patients subjected to open-heart surgery for acquired heart diseases. As molecular and cellular disorders anticipate the clinical symptoms, we came to a conclusion that increase of urine viscosity may be an early sign predicting the development of multiorgan abnormalities.