In vitro and in vivo investigations on the binary meloxicam-mannitol system.
2008
The objective of the study in rats was to investigate the
anti-inflammatory effects of pure meloxicam (ME) with
different particle sizes and of physical mixtures of the
binary ME-mannitol system. The level of local inflammation
was significantly decreased when the amount
of mannitol was the highest and the particle size of ME
was the lowest as well as the components had the
interparticulate interaction. The same results were
achieved in in vitro experiments.
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