A Review on AEG-1 oncogene regulating MicroRNA expression in Colon Cancer progression.

MicroRNAs (miRS) are a class of small non-coding RNAs which perform a crucial function in posttranscriptional gene regulation. Dysregulation of this microRNAs are associated with many types of cancer progression. In tumorigenesis, downregulated microRNAs might function as tumour suppressor by repressing onco- genes, whereas overexpressed miRs might function as oncogenes by suppressing tumour suppressor. Similarly, Metadherin (also known AEG-1/ LYRIC), is an oncogene, whose levels are found to be very high in various cancers and plays a crucial role in proliferation of cells and invasion. Our review focuses on the study which shows alteration of microRNA expression profile and suppression of carcinogenesis when MTDH/AEG-1 is targeted. It summarises about the studies where downregulation and upregulation AEG-1 and microRNAs respectively, alter the biological functions of the cell, such as proliferation and apoptosis. Studies have reported that AEG-1 can be direct or indirect target of microRNA which could provide a new-insight to know the underlying molecular mechanism and might contribute to the progress of new therapeutic strategies for the disease.