Enantiopure building blocks for the synthesis of 3-methyl-2-alkanols : Diastereoselective methylmetal addition to a chiral 2-methylaldehyde followed by lipase catalysed esterification

The racemic synthetic building block (2R*,3R*)-3-methyl-4-(phenylsulfanyl)butan-2-ol (2R*,3R*)-2 was obtained in a high diastereomeric ratio [95:5, (2R*,3R*)/(2R*,3S*)-ratio] by Lewis acid catal ...