Ausência de mutagenicidade de Solanum paniculatum L. em célula s somáticas de Drosophila melanogaster: SMART/asa

The lyophilized aqueous extract of Solanum paniculatum L. (jurubeba) leaves, a medicinal plant widely used by people as diuretic, in liver and spleen treatments, against fever and inflammation, underwent the SMART/wing test in somatic cells of Drosophila melanogaster for the evaluation of its mutagenic potential. We used three different concentrations of the leaf extract (2.5 mg.mL-1, 6.25 mg.mL-1, and 10 mg.mL-1), doxorubicin (DXR) as positive control, and distilled water with  5% sucrose as negative control. We employed three lineages of Drosophila in this experiment, flr³, ORR, and mwh. The  larvae derived from the standard cross (ST: flr³ females x mwh males) and the high bioactivation cross (HB: ORR females x mwh males) were chronically treated and the wings of the  emerging adults were analyzed. Our results showed no  mutagenic activity of S. paniculatum L. ST or HB crosses.