Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-sulfone analogs of the hormone 1α,25-dihydroxyvitamin D3

Abstract The new 24-phenylsulfone 4a , a low-calcemic analog of the natural hormone 1α,25-dihydroxyvitamin D 3 , is a potent (IC 50 = 28 nM) and highly selective inhibitor of the human 24-hydroxylase enzyme CYP24.