Expressions and roles of long non-coding RNA UCA1 in tumors

Urothelial carcinoma associated antigen 1 (UCA1) is a highly bladder cancer-specific long non-coding RNA (lncRNA), and it does not have the function of encoding protein. UCA1 differentially expre-sses in various fetal tissues, but its expression is turned off in most adult tissues. It reactivates during tumorigenesis. Researches indicate that UCA1 may regulate cell proliferation, apoptosis, metastasis and chemoresistance of tumors, such as bladder cancer, breast cancer and hepatocellular cancer. Key words: Neoplasms; Long non-coding RNA; Urothelial carcinoma associated antigen 1