Dietary inflammatory index and breast cancer risk by menopausal status and histological subtype.

1521Background: Inflammation plays an important role in cancer development. The Dietary Inflammatory index (DII) reflects the inflammatory potential of diet. We examined the association between the DII and breast cancer (BC) risk by menopausal status and histological subtype. Methods: Epi-GEICAM is a nation-wide case-control study that collected epidemiologic information, including diet, of 973 BC cases from 23 hospitals individually matched to 973 controls by age and residence. Cases were sub classified by tumor subtype: 1) Estrogen Receptor(ER)+ or Progesterone Receptor(PR)+ with Human Epidermal Growth Factor Receptor 2(HER2)-; 2) HER2+; and 3) ER-,PR-&HER2-. The association of the calorie density adjusted DII score (0-10) with BC risk was evaluated using conditional logistic regression models, adjusted by alcohol, body mass index, age at menarche, physical activity, smoking habit, education, history of breast alterations, family history of BC, age at first delivery and menopausal status. Heterogeneity ...