Fetal valproate syndrome: A case report

Sodium Valproate has been used as an antiepileptic drug for a long time. It is also increasingly used for treating bipolar disorder and other affective disorders. However, it is a potential teratogen and is one of the best depicted prototypes of the harmful effects of an antiepileptic drug. The most frequent congenital malformations associated with Fetal Valproate Syndrome are neural tube defects, congenital heart diseases, and orogenital abnormalities while inguinal and umbilical hernia, supernumerary nipple, bifid ribs, preaxial defect of feet, and postaxial polydactyly are less frequent abnormalities. Here, we report two cases of Fetal Valproate Syndrome in a 3.5-year-old boy and his 7-year-old brother with dysmorphic features.