Plasma and Serum Proteins Bound to Nanoceria: Insights into Pathwaysby which Nanoceria may Exert Its Beneficial and Deleterious Effects InVivo
2020
Nanoceria (CeO2, cerium oxide nanoparticles) is proposed as a therapeutic for multiple disorders. In blood, nanoceria becomes
protein-coated, changing its surface properties to yield a different presentation to cells. There is little information on the
interaction of nanoceria with blood proteins. The current study is the first to report the proteomics identification of plasma
and serum proteins adsorbed to nanoceria. The results identify a number of plasma and serum proteins interacting with
nanoceria, proteins whose normal activities regulate numerous cell functions: antioxidant/detoxification, energy regulation,
lipoproteins, signaling, complement, immune function, coagulation, iron homeostasis, proteolysis, inflammation, protein
folding, protease inhibition, adhesion, protein/RNA degradation, and hormonal. The principal implications of this study are:
1) The protein corona may positively or negatively affect nanoceria cellular uptake, subsequent organ bioprocessing, and effects;
and 2) Nanoceria adsorption may alter protein structure and function, including pro- and inflammatory effects. Consequently,
prior to their use as therapeutic agents, better understanding of the effects of nanoceria protein coating is warranted.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
0
Citations
NaN
KQI