Synthesis of a Key Intermediate of Novel Galbonolide Analogues via Efficient Construction of a Conjugated Diene System

The development of an efficient synthetic method enabled multi-gram synthesis of a key intermediate, which is useful for the modification at the C6-functional group of galbonolide analogues. The structure of a key intermediate including a conjugated diene was afforded by Horner–Emmons reaction, alkylation of Weinreb amide with alkyl lithium and a subsequent Wittig reaction.