Size-adaptive hepatocellular carcinoma detection from 3D CT images based on the level set method
2012
Automatic detection of hepatocellular carcinoma (HCC) from 3D CT images effectively reduces interpretation work.
Several detection methods have been proposed. However, there still remains a tough problem of adaptation detection
methods to a wide range of tumor sizes, especially to small nodules, since it is difficult to distinguish tumors from other
structures, including noise. Although the level set method (LS) is a powerful tool for detecting objects with arbitrary
topology, it is still poor at detecting small nodules due to low contrast. To detect small nodules, early phase images are
useful since low contrast in the late phase causes miss-detection of some small nodules. Nevertheless, conventional
methods using early phase images face two problems: one is failure to extract small nodules due to low contrast even in
early phase images, and the other is false-positive (FP) detection of vessels adjacent to tumors. In this paper, a new
robust detection method adapted to the wide range of tumor sizes has been proposed that uses only early phase images.
To overcome these two problems, our method consists of two techniques. One is regularizing surface evolution used in
LS by applying a new HCC filter that can enhance both small nodules and large tumors. The other is regularizing the
surface evolution by applying a Hessian-matrix-based filter that can enhance the vessel structures. Experimental results
showed that the proposed method improves sensitivity by over 15% and decreases FP by over 20%, demonstrating that
the proposed method is useful for detecting HCC accurately.
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