Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca2+ influx

Ji Jing,Lian He,Aomin Sun,Ariel Quintana,Yue-He Ding,Guolin Ma,Peng Tan,Xiaowen Liang,Xiaolu Zheng,Liangyi Chen,Xiaodong Shi,Shenyuan L. Zhang,Ling Zhong,Yun Huang,Meng-Qiu Dong,Cheryl L. Walker,Patrick G. Hogan,Youjun Wang,Yubin Zhou

Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca2+ influx

2015

Ji Jing
Lian He
Aomin Sun
Ariel Quintana
Yue-He Ding
Guolin Ma
Peng Tan
Xiaowen Liang
Xiaolu Zheng
Liangyi Chen
Xiaodong Shi
Shenyuan L. Zhang
Ling Zhong
Yun Huang
Meng-Qiu Dong
Cheryl L. Walker
Patrick G. Hogan
Youjun Wang
Yubin Zhou

Through a proteomic analysis of ER–PM junctions, Zhou and colleagues and Wang and colleagues discover that the transmembrane protein STIMATE is a positive regulator of STIM localization and function, thereby stimulating Ca2+ influx.

Keywords:

Transmembrane protein
Cell biology
Cell membrane
Endoplasmic reticulum
Biology
Regulator
Calcium signaling
STIM1
Biochemistry
base sequence
ca2 influx

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