Can Low Cost Indo Cyanine Green Florescence technique for Sentinel lymph Node Biopsy Replace Dual Dye (Radio-Colloid & Blue Dye) Technique In Early Breast Cancer: A Prospective Two Arm Comparative Study

Abstract Background To assess the detection & accuracy of sentinel lymph node (SLN) biopsy using low cost indocyanine green (ICG) fluorescence method & compare with gold standard dual dye method (Radio-colloid+ Methylene Blue dye). Material & Methods 100 patients with node negative early breast cancer assessed clinically and ultrasound axilla underwent SLNB procedure using technetium‐99m radio colloid (R), methylene blue dye (MB), and ICG. The detection rate of SLNs and positive SLNs, and the number of SLNs were compared. Injection safety of ICG and MB was evaluated. Results 100 female patients with a median age 52.3 participated in study. 68% had BMI Conclusion ICG fluorescence imaging permits real time visualization of lymphatic’s and provides an additional dimension to SLN biopsy that is safe and effective. These results confirm high sensitivity for fluorescence localization with comparable performance to the gold standard. ICG can reliably replace dual dye & be employed as a sole tracer for sentinel lymph node biopsy in early breast cancer.