Synthesis of monohydroxylated 2-azabicyclo[2.2.1]heptan-3-ones

Abstract Oxymercuration/demercuration of 2-benzyl-2-azabicyclo[2.2.1]hept-5-en-3-one ( 1 ) and biohydroxylation of the corresponding saturated lactam ( − )-( 8 ) are compared as methods for the preparation of monohydroxylated 2-azabicyclo[2.2.1]heptan-3-ones. © 1997 Elsevier Science Ltd.