Preparation method for isoxazole compounds

2011 
The invention belongs to the field of fine chemicals and relates to a preparation method for isoxazole compounds and related chemical technology. Alkyne and hydroxylamine serve as raw materials, and catalyzed by copper (Cu), composition of a novel isoxazole derivative is achieved by using the one-kettle two-step method. The preparation method for isoxazole compounds has the advantages of being mild in reaction conditions, good in functional group compatibility, wide in substrate scope, environment-friendly and the like. Because isoxazole ring is an important biological active group, the preparation method for isoxazole compounds is widely used in the field of medicine.
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