Isolation and Comparative Evaluation of Prosophis juliflora Gum as a Binding Agent with Standard Binder

Various plant gums like gelatin, acacia, alginic acid, guar gum, maize starch, and potato starch have been used as binder in pharmaceutical formulations. But still finding novel binder is useful in the pharmaceutical industry for manufacture of tablets. The Prosophis juliflora Gum was found for its binding property. Prosophis juliflora (Fabaceae family) is a shrub or small weed plant grows all over the world. Prosophis juliflora Gum has been evaluated for relevant properties and used as a binder to Aceclofenac tablets at concentrations of 8.0, 10.0 and 12.0%w/v. The granules were evaluated for moisture content, angle of repose, bulk density and tapped density, carr's compressibility index and hausner's ratio. The tablets were evaluated for thickness, weight variation, crushing strength, friability, disintegration time and dissolution profiles. Aceclofenac tablets containing maize starch as standard binder were produced and assessed comparatively. Results obtained indicated that Prosophis juliflora Gum performed as good as maize starch as a binder to Aceclofenac tablets.