BLyS antibody, and preparation method and application thereof

The invention discloses a BLyS antibody, and a preparation method and an application thereof. The BLyS antibody comprises one or more of a heavy chain CDR1, a heavy chain CDR2 and a heavy chain CDR3 in the heavy chain variable region of the BLyS antibody, and/or one or more of a light chain CDR1, a light chain CDR2 and a light chain CDR3 of the light chain variable region of the BLyS antibody, andthe amino acid sequences of all above heavy chains and light chains are respectively shown in the description. The BLyS has high affinity, and can remarkably effectively block a BLyS protein at a protein level and a cellular level to prevent the binding of the BLyS protein to a receptor. The BLyS antibody has no cross-reactivity with human APRIL and like protein antigens, has good biological activity, and can inhibit the proliferation of mouse B-cells induced by human BLyS, so the BLyS antibody can be used in the preparation of a medicine for preventing or treating diseases associated with BLyS expression or dysfunction.