창부도담탕이 비만 유도 흰쥐에 미치는 영향

Objectives: This study was designed to evaluate the efficacy of CBDT on obesity and lipid metabolism by using high-fat diet rats. Methods: Rats were divided into five groups. Normal group: Normal diet, Control group: High-fat diet, Positive control group: High-fat diet + Dietamin 4㎎/㎏/day, CBDT_Low group: High-fat diet + CBDT 250 ㎎/㎏/day, CBDT_High group: High-fat diet + CBDT 500 ㎎/㎏/day. Weight, food intake were measured every week. After 7 weeks, total cholesterol, HDL-cholesterol, LDL-cholesterol, TG, free fatty acid, AST, ALT, CBC were measured and mRNA expression of adiponectin, PPAR-γ, leptin were observed using RT-PCR of liver cells. Results: There was no difference in food intake between groups. Body weight tended to decrease compared with the Control group, but it wasn’t statistically meaningfull. The total cholesterol, LDL-cholesterol, TG, free fatty acid tended to decrease compared with the Control group. HDL-cholesterol tended to decrease compared with the Control group, but it wasn’t statistically meaningfull. WBC, RBC, Hb, PLT, AST, ALT were not affected by CBDT. The mRNA expression of Adiponectin, PPAR-γ, leptin, which are involved in the differentiation of adipocytes, was decreased compared with the Control group. Conclusions: Based on the results above, it is suggested that CBDT can be applied to hyperlipidemia clinically.