Laser mass spectrometry of volatile organic compounds for diagnosis of pathological processes

A method of rapid mass spectrometric analysis of volatile organic compounds (VOC) of biological samples at atmospheric pressure has been developed. The method uses laser plasma radiation for ionization of VOC molecules. Multivariate statistics was used for the mass spectra analysis. The possibility of identification of progressing oncological process in mice with analyzing the composition of VOCs of the urine samples was showcased.