The Hippocampus Is the Place to Be: Opioid Receptors and LTP

Nam et al. (2019) genetically modulate the expression of astrocytic μ-opioid receptors to reveal they are necessary for drug-induced conditioned place preference. These receptors trigger a mechanism involving metabotropic glutamate receptors to enhance hippocampal long-term potentiation, linking the conditioning to the location.