Dermocosmetic efficacy of a nutricosmeceutic concentrated oil-soluble fraction from Vitis vinifera grape marc on the skin hydrolipidic barrier and wrinkles

Grapes (Vitis vinifera) are one of the most widely-grown fruit crops in the world. Approximately 75% of the whole grape production is utilized into winemaking, while 25% of the original grape weight is grape pomace (skin, seeds and stalks), which is a by-product. The oil-soluble fraction of grape pomace is rich in phenolic compounds including flavonoids, carotenoids, phenolic acids, tannins, and stilbenes, high unsaturated fatty acids, vitamins (E, A and C) and phytosterols with economic importance to cosmetic, food and pharmaceutical industry. The objective of this study was to evaluate the cosmetic efficacy on skin balance, normalization, hydration and elasticity and on wrinkles prevention of dermocosmetic formulations containing grape seed oil extract on young and mature skin using in vitro and in vivo techniques.In vitro studies showed anti-aging effect through enhancement of cell detoxification, hydration, protection of cellular proteins, stabilization of connective tissues from UV-stress inducing hyaluronic acid synthase and stimulating collagen I and III synthesis.In vivo studies displayed wrinkles volume and depth reduction and a barrier protective effect inducing a high hydration of the skin.