Development of tetrazole bioisosteres in angiotensin II antagonists

Bernard Ferrari,Joelle Taillades,Pierre Perreaut,Claude Bernhart,Jean Gougat,P Guiraudou,Catherine Cazaubon,Alain Roccon,Dino Nisato,G. Le Fur,Jean-Claude Breliere

Development of tetrazole bioisosteres in angiotensin II antagonists

1994

Bernard Ferrari
Joelle Taillades
Pierre Perreaut
Claude Bernhart
Jean Gougat
P Guiraudou
Catherine Cazaubon
Alain Roccon
Dino Nisato
G. Le Fur
Jean-Claude Breliere

Abstract The application of acidic heterocycles as a substitute for tetrazole in the synthesis of potent non-peptide Angiotensin II AT1 receptor antagonists is described.

Keywords:

Combinatorial chemistry
Chemical synthesis
Angiotensin II
Molecule
Tetrazole
Angiotensin II receptor type 1
Organic chemistry
Stereochemistry
Chemistry
Heterocyclic compound

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