ANTITUMOR AGENTS. XXIII. HELENALIN, AN ANTITUMOR PRINCIPLE FROM ANAPHALIS MORRISONICOLA HAY
1977
A chloroform extract of the whole plant of Anaphalis morrisonicola HAY. showed significant antitumor activity against Ehrlich ascites carcinoma, Walker 256 carcinosarcoma, and P-388 lymphocytic leukemia. Systematic fractionation of the extract led to isolation and characterization of helenalin, a pseudoguaianolide, as the major active principle.
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