2-(Naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via ROS-mediated MAPK, AKT, and STAT3 signaling pathways in HepG2 human hepatocellular carcinoma cells

Yang Liu,Ying-Hua Luo,Shu Mei Li,Gui-Nan Shen,Jia-Ru Wang,Yi Zhang,Yu Chao-feng,Wan-Ting Xu,Yu Zhang,Tong Zhang,Hui Xue,Hong-Xing Wang,Yang Cui,Ying Wang,Cheng-Hao Jin

2-(Naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via ROS-mediated MAPK, AKT, and STAT3 signaling pathways in HepG2 human hepatocellular carcinoma cells

2019

Yang Liu
Ying-Hua Luo
Shu Mei Li
Gui-Nan Shen
Jia-Ru Wang
Yi Zhang
Yu Chao-feng
Wan-Ting Xu
Yu Zhang
Tong Zhang
Hui Xue
Hong-Xing Wang
Yang Cui
Ying Wang
Cheng-Hao Jin

Abstract1,4-naphthoquinone and its derivatives have attracted widespread attention due to their multiple biological activities, such as induction of cancer cell apoptosis; however, most of these co...

Keywords:

Reactive oxygen species
Signal transduction
Protein kinase B
Biochemistry
Apoptosis
STAT3
1,4-Naphthoquinone
Cancer research
MAPK/ERK pathway
Chemistry
Cancer cell
Hepatocellular carcinoma
Thio-

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