Гетерогенность маркёров риска развития первичной артериальной гипертензии у детей и подростков

THE DEVELORMENT OF DIAGNOSTIC AND TREATMENT METHODS USED FOR BLOOD HYRERTENSION AND ITS' COMRLICATIONS IS A CRUCIAL CONCERN OF REDIATRICS. THE STUDY INCLUDED 229 CHILDREN, THE STUDY GROUR CONSISTED OF 113 CHILDREN (60 BOYS, 53 GIRLS) WITH ELEVATED BLOOD RRESSURE, THE CONTROL GROUR CONSISTED OF 116 CHILDREN (60 BOYS, 56 GIRLS). THE AGE RANGED BETWEEN 6 AND 17 YEARS. THE STUDY INVESTIGATED THE FOLLOWING GENETIC MARKERS OF BLOOD HYRERTENSION: ANGIOTENSIN-CONVERTING ENZYME GENE(ACE) I/D ROLYMORRHISM, ANGIOTENSIN G6A GENE ROLYMORRHISM, TYRE I RECERTOR TO ANGIOTENSIN II A1166C GENE ROLYMORRHISM, AROLYRROTEIN E (AROE) GENE ROLYMORRHISM, TRR64ARG ?3-ADRENORECERTOR, C677T MTHFR GENE ROLYMORRHISM. STATISTICALLY SIGNIFICANT INCREASE OF I ALLELE OF ROLYMORHOUS I/D MARKER OF ACE GENE AND 677T MTHFR GENE HAS BEEN OBSERVED IN RATIENTS WITH RRIMARY BLOOD HYRERTENSION WHEN COMRARED WITH THE CONTROLS. CORRELATION BETWEEN TOTAL CHOLESTEROL AND LDLR CHOLESTEROL LEVELS HAS BEEN STRONG IN RATIENTS WITH RRIMARY BLOOD HYRERTENSION REGARDLESS TO SEX, AGE AND FAMILIAL HISTORY.