The current role of radiotherapy in paraplegia due to extramedullary hematopoiesis in thalassemia. A case report and a review of the literature

Spinal cord compression as a consequence of mass lesions due to extramedullary hematopoiesis is a well - described but rare syndrome occurring in thalassemia and some other hematologic conditions. Generally presents as parapa­resis with sensory impairment. Treatment option mostly includes surgery and/or radiotherapy. After low-dose radiotherapy a rapid and durable response occurred in a patient with thalassemia. No side effects were encountered and the patient has been stable neurologically. We hereby report a case of thalassemia with paraplegia treated successfully with low-dose radiotherapy.