SYNTHESIS AND CYTOTOXIC ACTIVITY OF α-SANTONIN AMINO-DERIVATIVES

S. G. Klochkov,S. V. Afanas’eva,A. N. Pushin,G. K. Gerasimova,N. K. Vlasenkova,Yu. N. Bulychev

SYNTHESIS AND CYTOTOXIC ACTIVITY OF α-SANTONIN AMINO-DERIVATIVES

2009

S. G. Klochkov
S. V. Afanas’eva
A. N. Pushin
G. K. Gerasimova
N. K. Vlasenkova
Yu. N. Bulychev

Previously unknown amino-derivatives of the natural sesquiterpene lactone α-santonin were synthesized. The activity of the products against several human tumor-cell lines was studied.

Keywords:

Organic chemistry
Sesquiterpene lactone
Biochemistry
Cytotoxic T cell
Santonin
Chemistry
Michael reaction
Stereochemistry
amino derivatives

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