Distinctive maturation of in vitro versus in vivo anti-CD40 mAb-matured dendritic cells in mice.

Summary:Dendritic cells (DCs) can be matured by CD40 stimulation to upregulate their MHC class II/peptide complexes and costimulatory molecule surface expression to become adept at presenting antigen to and activating naive T lymphocytes. The use of anti-CD40 antibodies as adjuvants for DC-based the