Traumatic renal failure in the rat.

A systematic study of the variables connected with the production of renal damage following a crushing limb injury in the rat has been made. The state of hydration of the animal immediately prior to and following the crushing injury appears to be the most critical variable. Myoglobin, while it intensifies the renal dysfunction, is not necessary for its production. The area involved in the crush as well as the amount of renal reserve, are important factors. Various steroid hormones were ineffective in altering the course of the disease.