Caco-2 cell permeability modelling

An image reading apparatus in which reference density data corresponding to a reference document having a predetermined reference density is stored in advance, while a plurality of gamma correction curves are also stored in advance. Light intensity data indicative of the intensity of light reflected from the reference document is subjected to a shading correction. One gamma correction curve is selected from the plurality of gamma correction curves in correspondence to a difference in output level between the reference density data and outputted density data obtained by converting the shading corrected light intensity data. Gradation of the outputted density data is adjusted based on the selected gamma correction curve.